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What do Exosomes Do In Comparison to Stem Cells?

Stem cells and exosomes are two parts of the same coin. Exosomes are tiny extracellular vesicles derived from mesenchymal stem cells (MSCs), with comparable therapeutic effects to stem cells. Exosomes are released naturally from a cell and play an important role in cell-to-cell communication. Exosomes transfer functional cargos like miRNA and mRNA molecules, peptides, proteins, cytokines and lipids from MSCs. While exosomes were originally thought to be involved only in the recycling of cellular waste, it is now clear that they play a very important role in intercellular communication. In fact, exosomes have been shown to transfer both genetic and epigenetic information between cells. This process is thought to be important for the development and maintenance of tissue homeostasis. Recently, exosomes have been isolated from stem cells and are being studied for their potential use in cell therapy. Unlike stem cell therapy, exosome therapy does not involve the transfer of live cells, they are not able to replicate. Instead, exosomes are injected into the body, where they can target damaged tissue and promote healing using their high growth factor receptors as well as being small enough to cross the blood-brain barrier. 

Additionally, exosomes have been shown to mediate the immune response and promote wound healing with injured or diseased tissues and organs. Studies reported in experimental models that exosomes alone, are responsible for the therapeutic effects of MSCs stem cells. For example, exosomes isolated from stem cells are currently being investigated as a better therapy for treating a variety of diseases. (See list below) As research into the biology of exosomes continues, it is likely that even more applications will be discovered and have a major impact on the future of medicine.

Exosomes are important for many reasons. 

  1. Remove waste products from cells. 
  2. Regulate the immune system. 
  3. Role in stem cells ability to differentiate 
  4. Role in tumor progression cancer metastasis. 
  5. Exosomes can be used for diagnosis and prognosis of disease.

Currently, there is a lot of research being done on exosomes and their potential uses in the medical field.

Exosome and stem cell therapy benefits include:

  • Reduces inflammation caused by old age, illness, and disease
  • Supports healthy metabolic function & energy 
  • Helps manage and may relieve chronic pain by promoting healing
  • Promotes tissue and cell repair
  • Anti-Aging
  • Increases immune health by helping to fuel your immune system
  • Promotes brain health, aids in reversing neurological damage to improve cognitive function and mental clarity 
  • Autoimmune disorders
  • Alzheimer’s disease
  • Traumatic brain injury (may promote the growth of new neuron cells)
  • Cartilage tears and bone tissue regeneration 
  • Improvement of hair growth (may promote hair follicular growth)

At our clinic, we administer this procedure one of two ways: direct, targeted injections or IV therapy to slowly release throughout the body. A normal procedure takes about 45 minutes to 1 hour from start to finish. Both treatments are incredibly versatile and can treat a wide variety of health concerns. A highly trained physician can evaluate you and recommend  the most appropriate and beneficial regenerative therapy treatment.

The benefits of exosome therapy can last for years after your treatment plan is complete. This varies depending on the nature and severity of any condition being treated, but many people see significant drops in symptoms within just 1 session! Either treatment can improve your quality of life and help keep you healthy, well and active!

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Dr. Juan P Nieto, M.D

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Dr. Andrew Bernstein, M.D

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