What Does Muse Cell Therapy Involve? A Step-by-Step Look at a Typical Protocol
Medically reviewed by Dr. Charles Pereyra, MD — Medical Director, Springs Rejuvenation. Last reviewed October 7, 2026.
Written by the Springs Rejuvenation regenerative medicine team from direct clinical experience administering stem cell and exosome protocols at our Aventura, Miami center.
Patients considering muse cell therapy usually want a concrete picture: what happens, in what order, and why. While protocols vary by clinic and by individual, research-informed programs follow a recognizable structure modeled on how Muse cells have been studied in clinical trials.
Step 1: Physician Consultation and Screening
Everything starts with candidacy. In published trials — such as the first-in-human CL2020 study in heart attack patients (Noda 2020) and the randomized stroke trial by Niizuma and colleagues (2023) — participants were screened against defined criteria before receiving cells. A responsible clinic mirrors this: medical history, current medications, relevant imaging or labs, and a frank conversation about goals. At Springs Rejuvenation, Dr. Charles Pereyra's team screens candidates first and treats second; some people are advised to wait or to pursue other options.
Step 2: Baseline Labs and Planning
Baseline bloodwork establishes safety parameters and a reference point for follow-up. The therapy plan — cell preparation, route, and timing — is set by the physician based on the individual's profile.
Step 3: Administration
In the Japanese clinical trials, Muse-based cell products were delivered intravenously, taking advantage of the cells' described ability to home toward damaged tissue via the S1P-S1PR2 axis (Yamada 2018). A typical clinic session involves IV placement, slow infusion under observation, and a monitoring period afterward. Intravenous delivery of cell-based products has decades of safety-focused study behind it, beginning with randomized trials such as Hare 2009 in cardiology.
Step 4: Follow-Up
Trials followed participants for months, not days. A quality program schedules structured check-ins to track how you are doing and to document your course over time.
How long does a muse cell therapy session take?
Plan for several hours including preparation, infusion, and observation, though the infusion itself is typically shorter. Your clinic will give exact timing at consultation.
Is muse cell therapy painful?
Intravenous administration involves a standard IV line. Most discomfort reported in trials of IV cell products was mild and transient, but your physician will review risks individually.
How many muse cell therapys are needed?
Published trials generally studied single administrations. Whether repeat sessions make sense is an individualized physician decision, not a package deal — be cautious of clinics that sell multi-session bundles before evaluating you.
Is muse cell therapy FDA approved?
No. It is investigational in the United States. Research to date is encouraging but ongoing, and a credible clinic — including Springs Rejuvenation — will say so plainly.
Medical Disclaimer: Stem cell and exosome therapy is not an FDA approved therapy and is considered to be in the experimental stages. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Springs Rejuvenation processes exosomes in an FDA approved lab. Individual results may vary. This content is reviewed for medical accuracy by Dr. Charles Pereyra, MD, Medical Director of Springs Rejuvenation, and is provided for educational purposes only. Always consult a qualified physician.