Sacroiliac (SI) Joint Dysfunction: Regenerative therapy Options
Medically reviewed by Dr. Charles Pereyra, MD — Medical Director, Springs Rejuvenation. Last reviewed June 22, 2026.
Written by the Springs Rejuvenation regenerative medicine team from direct clinical experience administering stem cell and exosome protocols at our Aventura, Miami center.
The sacroiliac (SI) joints connect the base of the spine to the pelvis, and dysfunction here is a common but frequently missed cause of low back and buttock pain. Patients who have cycled through other diagnoses without relief sometimes find that the SI joint was the real culprit. For the right case, regenerative approaches are one option worth discussing — after the SI joint is confirmed as the source.
What the SI joint does
The SI joints transfer load between your spine and legs and normally move very little. When they become irritated, inflamed, or unstable, the result can be a deep, one-sided pain that worsens with sitting, standing from a chair, or rolling over in bed. Because the symptoms overlap with other back conditions, careful assessment is essential.
Where regenerative options may fit
Exosome and platelet-rich plasma approaches aim to support the joint and surrounding ligament environment and reduce symptoms. At Springs Rejuvenation these are considered only after the SI joint is confirmed as the pain source, and they are delivered with image guidance as part of a broader plan that includes the stabilization work the pelvis needs.
Reading the evidence with care
Research on regenerative injections for SI joint dysfunction is earlier and smaller than for larger joints, so expectations should stay grounded. Some patients report meaningful relief, but the field lacks large long-term trials, and the responsible framing is supportive care rather than a certain fix. Matching the approach to a correctly identified source remains the most important factor.
How do I know the SI joint is really the problem?
A careful examination, sometimes supported by diagnostic injections, helps confirm the SI joint as the source before any regenerative plan is considered.
Who tends to be a candidate?
Patients with confirmed SI joint pain who want to try a conservative, regenerative route first are the most reasonable fit.
What else supports recovery?
Pelvic stabilization and targeted strengthening are central. Regenerative support is added to those fundamentals.
The Springs approach
We work to confirm whether the SI joint is truly driving your pain, then decide together whether a regenerative plan makes sense. A free consultation is the simplest way to get clarity on stubborn low back or buttock pain.
Medical Disclaimer: Stem cell and exosome therapy is not an FDA approved therapy and is considered to be in the experimental stages. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Springs Rejuvenation processes exosomes in an FDA approved lab. Individual results may vary. This content is reviewed for medical accuracy by Dr. Charles Pereyra, MD, Medical Director of Springs Rejuvenation, and is provided for educational purposes only. Always consult a qualified physician.